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Worryingly however, 26.8% of patients had to discontinue the trial due to the severity of side-effects, although it must be noted that this was in part due to the lack of a run-in (A time frame where drug dosage is started from a low dosage and then escalated over time until the highest tolerable dose for the patient is reached) [40]

Pharmacol Res (2021) 170:105742

First, BCKAsthe immediate transamination products of BCAAsaccumulate when BCKDH flux is impaired and directly inhibit insulin-stimulated Akt phosphorylation, thereby impairing glucose uptake and mitochondrial oxygen consumption through mTORC1-independent routes ( Figures 2 , 3

Seitz & Mueller, 2014

IV therapy delivers amino acids through a drip while injections offer a quick, efficient option

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