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Lastly we identified a POAG-associated intronic variant on chromosome 9 which encodes UBAP2 , a gene associated with the neurodegenerative disease amyotrophic lateral sclerosis 44 ,in which astrocytes play a role in both ALS disease and in changes to the optic nerve head in glaucoma 45

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Conversely, through their distinct physicochemical properties and physiological activities, bile acids further exert selective effects on intestinal microorganisms, promoting or inhibiting the growth of specific taxa and ultimately influencing the overall structure of the gut microbial community