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For patients using insulin or sulfonylureas, proactive dose reduction of these medications should be considered before tirzepatide escalation to mitigate hypoglycemia risk, with increased glucose monitoring during the transition

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The Medicines and Healthcare products Regulatory Agency (MHRA) in the UK has similarly reviewed the data and continues to monitor reports closely, but has not issued specific warnings linking Mounjaro to increased suicide risk

Role in disease [edit] Mutations in the first SOD enzyme (SOD1) can cause familial amyotrophic lateral sclerosis (ALS, a form of motor neuron disease)