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While some studies they reviewed were positive regarding improving cognitive functioning, others had mixed results

Moreover, disparities in access and coverage, particularly for oral formulations and newer agents, hinder equitable implementation

The human safety dataset is smaller than for older peptides because MOTS-c is a relatively recent therapeutic, but the available evidence and clinical experience point to a clean profile in healthy patients without contraindications

Regular monitoring of kidney function and overall response to the medicine is advised in elderly individuals

10.1038/s41564-018-0337-x Nat Microbiol

Developing this drug is a huge effort with high expectations for it