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3.5 Subgroup analysis To address the considerable heterogeneity observed across studies, we performed subgroup analyses focusing on three confounding factors (animal species, treatment agents, model drugs and dosages), to identify the sources of heterogeneity for the five primary outcomes (AST, ALT, SOD, MDA, GSH)

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Patients should compare the limited and emerging MOTS-c evidence with established treatments, contraindications, monitoring needs, and individual clinical circumstances