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Mahroo et al., 2021)

doi: 10.1007/s00125-007-0596-1

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Almroth, H

Consistent with the notion that GSH per se does not regulate mTORC1 and the ISR, depletion of intracellular GSH exacerbated the loss of mTORC1 signaling upon cystine deprivation, but was without observable effect in the presence of cystine (Fig

We found that blocking the translation of NRF2 prevented GSH accumulation ( Figure 7F ) as well as negated the immunosuppressive action of melatonin treatment ( Figures 7H, I )