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This message tells the cells: Time to upgrade the power grid! The cells respond by starting Mitochondrial Biogenesis (building new generators) and switching their fuel source to burn the most powerful, long-lasting fuel they have: stored fat

Energy buffering systems, including phosphocreatine (PCr), inorganic phosphate (Pi), and creatine, are also altered across brain regions in MDD and correlate with symptom severity [63,64,65]

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Patient weight over time

(PubMed) Birks J