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These findings support continued interest in Epitalon as part of broader research into healthy aging and nervous system resilience
Oxidative stress-induced glutathionylation has been recognized as a mechanism for induction and regulation of several proteins, including Grx (glutaredoxin), Trxs (thioredoxin) and GSTs, which are involved in environmental stress responses (Dixon et al
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Fatigue is another commonly reported effect, occurring in 8% to 12% of participants
Regarding the glutamate metabolic pathways, they also found some limited evidence of altered expression of the excitatory amino acid transporter-2 (synaptic re-uptake), glutamine synthetase (glial change of glutamate to glutamine), and glutaminase (presynaptic change from glutamine to glutamate prior to vesicular re-packaging)