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The slight increase in weight reduction caused by semaglutide compared to a less expensive alternative (top-dose phentermine/topiramate) does not offset semaglutide's much higher cost when considering cost and effectiveness together." Obesity treatment with drug therapy and lifestyle counselling is now recommended by the American Academy of Pediatrics for adolescents ages 12 years and older with obesity, and several medications have been approved by the FDA for use in teenagers

The Ozempic Flip-Flop West Virginia gave obesity drugs to teachers and state employeesthen took them away

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It took several years after various publications on the benefits of GLP-1 in humans from different academic labs for pharmaceutical companies, including the above-mentioned Novo Nordisk, to become interested in it