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When the cells were warmed to 37 C for 10 min so that endocytosis takes place, hemeAF546HPX is detected intracellularly in vesicles, as indicated by punctate staining (Figures 2E,F)

Wegrowski, Y., Maquart, F., & Borel, J

Large CMNs may develop a cobblestone surface with color variation

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Kizilaslan, N., & Erdem, N

The propeptides are cleaved by endopeptidases after secretion into the extracellular space (extracellular activation) or before they are incorporated into storage vesicles (intracellular activation) [21, 22]