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The optic fractionator frame method was used to count Polymorphonuclear Leukocytes (PMNLs) in the lamina propria of six tissue sections for each guinea pig

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Gupta et al., 2012

Their adverse effects are hypoglycaemia, GIT disturbances, cholestatic jaundice, agranulocytosis, aplastic and hemolytic anemia, generalized hypersensitivity and dermatological reactions [116]

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Data from a Phase 2 clinical trial (n=338), published in August 2023, showed that in obese patients, 48 weeks of treatment resulted in an average weight reduction of 22.8% in the 8 mg group and 24.2% in the 12 mg group