However, this may change
Many patients notice pain relief and increased function within weeks, with additional improvement over a few months
They don't directly target the brain-gut axis the way some IBS-specific medications do, but they support the underlying gut tissue and immune signaling
As examples, some of these predictions are stated here: Under conditions of B12 insufficiency, excess folic acid intake will cause the following: Diversion of holoTC from serum to hemopoietic cells to support reticulocyte proliferation Loss of holoTC in urine due to interference of its reuptake by the megalin-receptor complex in the renal tubules Reduced availability of holoTC to the liver, brain, and other tissues due to its diversion to the hemopoietic system and loss in the urine
The calculation depends on your final concentration
Physician and obesity specialist Spencer Nadolsky, MD, for instance, in search of relief for his tennis elbow, took the leap and sourced the peptide from a compounding pharmacy