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Retatrutide's known side effect profile from trials includes nausea, vomiting, diarrhoea, decreased appetite, and injection-site reactions effects consistent with other GLP-1-based therapies

For example, SGLT2i should be prioritized in patients with HF or CKD, while GLP-1 RAs may be more favorable in patients with higher ASCVD risk or obesity

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And of course they suffer a disproportionate burden with not just cardiovascular disease, but also type 2 diabetes, chronic kidney disease, and other medical conditions. Aboriginal led health care is key, here