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5 Karg E, Odh G, Wittbjer A, Rosengren E, Rorsman H

Huang X, Fang Q, Rao T, Zhou L, Zeng X, Tan Z, Chen L, Ouyang D (2020) Leucovorin ameliorated methotrexate induced intestinal toxicity via modulation of the gut microbiota

28,29 While Phe 28 is essential for affinity and activity, it is interesting that replacement with a synthetic residue hexafluoroleucine resulted in only a moderate loss in binding affinity and biological activity (10- and 5-fold, respectively)

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IGF-1 DES has 20-30 minute half-life, minimal IGFBP binding, highest receptor affinity and potency, localized effects at injection site, and requires frequent dosing for sustained effects

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