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Here we show that oral intake of long-term oscillating glucose (LOsG) (4 times/day) for 38 days, which produces physiological glycemic variability in rats, can lead to -cells gaining metabolic memory in reactive oxygen species (ROS) stress

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Importantly, this effect is immunomodulatory, not immunosuppressive , meaning it calms excessive inflammation without shutting down immune defense

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Standard oral formulations achieve only 0.7% bioavailability, limiting blood level increases compared to IV delivery