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i , Six residues around the intracellular ionic lock of GLP-1R (H180 2.50b , L251 3.54b , L349 6.40b , S350 6.41b , T353 6.44b and Y402 7.57b ) were selected to calculate the solvent-accessible surface areas (SASA) using the program freeSASA 49

A change in membrane potential was required to be at least 2 mV in amplitude in response to drug application

Furthermore, GLP-1R affects the mucosal membrane in the gastric tract by decreasing gastric secretions, which restrict gastric acid secretions and motility [49,50,51]

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It's important to note that these medications carry a boxed warning for risk of thyroid C-cell tumors and are contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)