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Patients starting or escalating GLP-1 medications should be educated about warning signs that warrant medical evaluation

Some patients using weight loss injections report eating considerably less than before treatment, which may contribute to feeling cold

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The macrovesicular and the microvesicular fatty change (vacuolation) generally located at the cell periphery stains positively for Oil Red-O and the membranes surrounding these lipid vacuoles stain positively for adipophilin (a protein that forms the membrane around non-lysosomal lipid droplets) but negative for LAMP-2 (a lysosome-associated protein) by immunohistochemical techniques (Obert et al