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Graphical Abstract Similar content being viewed by others Introduction There are presently nine classes of glucose-lowering agents used in the treatment of type 2 diabetes in Europe and several more are available in other regions (Table 1) [1, 2]

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GLP-1 receptor agonists like Ozempic and Wegovy have been shown to drive average weight loss of 1015% of body weight within a year, largely by reducing appetite and slowing gastric emptying

All observations from preclinical (swine) models

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A number of technologies for the oral delivery of peptides typically insulin have been described in the literature, including nanoparticles, microneedle devices, self-emulsifying drug delivery systems, peptide conjugation, and permeation enhancers (reviewed in detail by Durn-Lobato et al