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AD-specific lactylation dysregulation centers on the glycolysis-H4K12la-PKM2 positive feedback loop in hippocampal microglia and tau lactylation in vulnerable neuronsthis dual-cell lactylation network directly promotes A phagocytosis impairment and tau pathological aggregation (Zhao and Xu, 2022), a mechanism not observed in ischemia-induced acute injury or PDs dopaminergic neuron-specific degeneration

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Catalytic-enhanced lactoferrin-functionalized Au-Bi(2) Se(3) nanodots for Parkinsons Disease Therapy via reactive oxygen attenuation and mitochondrial protection

The recognition of this lesion is clinically important, since it might be misdiagnosed as a malignancy, such as malignant melanoma by the unwary