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Conformational signatures in beta-arrestin2 reveal natural biased agonism at a G-protein-coupled receptor

10.1016/j.biopha.2018.08.088

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Notably, the treatment of animals with mitochondrial antioxidants was able to effectively protect the diaphragm from muscle fiber atrophy and contractile dysfunction induced by mechanical ventilation, further confirming the critical role of ROS in mediating muscle atrophy (151)