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152 In M1 macrophages, PPP-generated NADPH is essential since ROS production is maintained by NADPH oxidase

However, the VPA model was specifically selected for its ability to: (1) mimic the gut microbiota dysbiosis observed in ASD patients [45], which genetic models often fail to reproduce [44]

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Conventional antioxidant strategies ROS-based antioxidant strategies are common therapeutic approaches that have been widely applied in both clinical and basic research fields

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