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"Fatigue, headaches and GI issues have also been reported

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When to See a Dermatologist While freckles are mostly harmless, its important to consult a dermatologist if you notice: Sudden changes in the colour, size, or shape of freckles Persistent dark spots or irritation after sun exposure They look different from your usual spots A dermatologist can rule out skin cancer, recommend the right treatments, and guide you on laser freckles removal or safe topical options

View source PubMed / Neurology Randomized clinical-trial context for a mitochondria-targeted peptide in a specific diagnosed condition