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The exact CYP enzyme involved in methimazole and/or PTU metabolism is not characterized yet, hence further investigations are required to elucidate the possible role of enzyme variation in the hepatotoxicity induced by these drugs

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2021, May, 27;593(7860):50205 Al-Aly Z, Davis H, McCorkell L, Soares L, Wulf-Hanson S, Iwasaki A, et al

Compared with control (i.e., + ) cells, 0 cells expressed mitochondrial genes at undetectable levels and were entirely deficient in oxidative metabolism, as detected using Seahorse technology (Fig S2C and D)

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