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Xuemin H, Siying W, Xixiang T, Zheyao W, Rui Z, Shasha L, Rong G, Jin W, Yanhua Z, Dong F, Ting L, Ruiping P, Zhaotian Z, Shiyi W, Li Z, Heying A, Yan L, Shaochong Z, Guojun S, Yanming C

The current work is predicated on previous suggestions that GLP-1 activity depends on adoption of a reverse turn near the peptide N-terminus, which raises the possibility that the N-terminal helical conformation in the cryo-EM structure of receptor-bound GLP-1 12 may not fully capture structural requirements for signaling

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These studies should evaluate the impact of varying cessation intervals on gastric emptying and aspiration risk across different patient populations, including those with obesity, diabetes, delayed gastric emptying, or undergoing high-risk procedures