Other add-ons sometimes appear (names like Lipo-C, carnitine, B-complex), depending on the clinic
In the randomized placebo-controlled HOME trial of 390 adults with type 2 diabetes (de Jager and colleagues, Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency, BMJ, 2010), metformin lowered serum B12 by a mean of 19 percent over 4.3 years
Everyone, but especially those who are most at risk of being B12 insufficient or deficient
The honest comparison is about dose, time, what else you want in the bag, and how often you plan to come in
For individuals with low vitamin B12 levels or difficulty absorbing nutrients through diet alone, this method can be especially beneficial
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