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Mechanisms of GLP-1 Receptor Agonist-Induced Weight Loss: A Review of Central and Peripheral Pathways in Appetite and Energy Regulation

Common reactions include: Bloating and gas Diarrhea Decreased appetite Metallic taste in mouth A concern with long-term metformin use is vitamin B12 deficiency [20]

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Average weight loss at week 52 was 15.6 percent, and at week 104 (two years), it was 15.2 percent