Combined therapy that involves the inhibition of Gln metabolism alongside PD-L1 blockade has been shown to enhance the anti-tumor immune response of T cells ( in vivo and in vitro ( DON, which exhibits high structural similarity to Gln, enhances the cytotoxic effects of CD8+ T cells while inhibiting Gln metabolism in cancer cells
This can be described as a cause-and-effect sequence that exists in addition to the effect of the individual factors separately
Although bone turnover markers CTX and P1NP declined, differences among groups were not statistically significant
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10.1042/bj3230159 188 LiuJ.Garcia-CardenaG.SessaW
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