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The decrease in Nrf2 first leads to an increase of unbound Keap1, due to the reduced complex formation with Nrf2 (Fig 3C

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It has been studied in clinical trials involving over 2,000 individuals, is approved for use in over 30 countries (primarily for hepatitis and cancer immunotherapy), and has specific published research in autoimmune populations including RA, SLE, and MS patients

10.1016/j.freeradbiomed.2014.07.019 46 PittsM.HoffmannP

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So, at this time, we reserve our highest recommendation for forms and dosages that are most supported by current research