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Disulfide cyclized tripeptide analogues of angiotensin IV as potent and selective inhibitors of insulin-regulated aminopeptidase (IRAP)

Dihexa's plasma half-life is estimated at 24 hours in rodent models, though CNS half-life may differ due to blood-brain barrier kinetics and receptor internalization dynamics

Blood 113(9):19922002 Zhang L et al (2015) Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas

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10.7150/jca.33457 J

Arthritis Rheum (2012) 64(6):17309