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A 2026 biopharmaceutical review in a journal I do not trust said there is no identified high-affinity receptor, no validated molecular target, and a wide disconnect between the tidy preclinical effects and any coherent pharmacology

It is recommended to store them in a cool, dry environment, typically refrigeration or freezing, to preserve their efficacy

Adeola HA, Bello IO, Aruleba RT, Francisco NM, Adekiya TA, Adefuye AO, et al

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Stronger is not better if it causes irritation