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These drugs mimic a natural hormone in the body called glucagon-like peptide-1 (GLP-1) , which plays an important role in regulating blood sugar and digestion

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Versus GLP-1 receptor agonists: Tirzepatide has demonstrated superior HbA1c reduction and weight loss compared to semaglutide 1 mg in the SURPASS-2 trial

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10.1039/9781788016216-00151 285 ValkoM.LeibfritzD.MoncolJ.CroninM

Because it engages all three, retatrutide is often described as a triple agonist. For comparison, tirzepatide is a dual agonist (GLP-1 and GIP) and semaglutide is a single agonist (GLP-1)