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It is usually induced in animal models by immunization with antigens from the thyroid, such as thyroglobulin or thyroid peroxidase, which induce the production of autoantibodies that attack thyroid cells (Liu et al

we can see several mechanisms have been attributed to this loss of responsiveness to the hormone

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GPER-1 belongs to the family of G protein-coupled receptors, and, in humans, its gene is located in chromosome 7p22.3, which encodes a sequence of 375 amino acids with a relative molecular mass of 41 kDa

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