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Even if semaglutide and tirzepatide do not meaningfully enter breast milk, GLP-1 therapy during breastfeeding carries indirect risks that deserve serious attention

The protocol from Celsis for assessing microsomal- dependent drug metabolism was followed with minor adaptations

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The substitution that does the real work is D-Ala2, which blocks cleavage by dipeptidyl peptidase-4, the protease that degrades native GHRH within minutes