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The same GLP-1 activity that supports appetite control can also slow gastric emptying, meaning food moves more slowly through the stomach

After accounting for a wide range of potentially influential factors including patient age, sex, socioeconomic status, diabetes severity, and a history of mental ill health, use of GLP-1 receptor agonists was not associated with an increased risk of suicidality compared with DPP-4 inhibitors (3.9 v 3.7 per 1000 person years, respectively) or an increased risk of suicidality compared with SGLT-2 inhibitors (4.3 v 4.6 per 1000 person years, respectively)

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In the adrenal medulla, Ang II promoted the synthesis of norepinephrine, which contracted the vascular arteriolar smooth muscle and increased blood pressure

27 Plateaus on GLP-1 medications like semaglutide often occur after a period of successful weight loss, typically estimated between 9 and 12 months 46 or around 60 weeks of treatment

10.1016/0014-5793(89)81332-8 FEBS Lett