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The result is not one therapeutic system, but two overlapping systems built on the same pharmacological foundation

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In addition to its effects on insulin, GIP plays a crucial role in fat accumulation by promoting the activity of adipocyte-expressed lipoprotein lipase and promoting bone formation by preventing osteoclast apoptosis, as evidenced by the thinner bone trabeculae seen in mice lacking GIP receptors [20,21,22]

This altered carnitine metabolism has been implicated in the multiple organ failure in subjects with systemic inflammatory response syndrome and toxic shock

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