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This estimand will be analysed in participants who undergo follow-up RBANS assessment at 180 days (+0, 10 days) and who have taken at least 80% of the study medication (principal stratum strategy) Secondary estimand safety 1

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Chronic activation of the hypothalamic-pituitary-adrenal (HPA) axis leads to prolonged elevation of cortisol, which can downregulate serotonin and dopamine receptor expression in areas such as the prefrontal cortex and limbic system, contributing to mood disorders and impaired cognitive function