Taken together, these pieces of evidence suggest that the biosynthesis rate of glutathione might be involved in nephrotoxicity by increasing cellular retention of Hg, altering the redox balance and leading to cytotoxicity 46,47 , possibly via mitochondria dysfunction by altering the ratio of reduced (GSH) to oxidized (GSSG) glutathione in this organelle 48,49
Bes et al
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GSH depletion studies: using a laboratory inhibitor such as buthionine sulfoximine (BSO) and confirming the result by direct GSH measurement
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