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Alternatively, the plateau could reflect the fraction of the hyperpigmented area that is sensitive to niacinamide treatment

Both figures exceed the 20.9% mean weight loss seen with semaglutide 2.4 mg at 68 weeks in STEP-1 (N=1,961) [6], and the 22.5% seen with tirzepatide 15 mg at 72 weeks in SURMOUNT-1 (N=2,539) [7]

International Journal of Molecular Sciences Obeid R, et al

This molecule, termed a Twincretin, allows for weight loss exceeding twenty percent, a result historically reserved for bariatric surgery [Pocket Manual di Terapia]

Mark Hyman, Functional Medicine Physician and NYT Best Selling Author Dr