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Targeting oligodendrocytes to treat diabetic BBB NG2-glia lower the permeability of brain endothelial cells to sodium fluorescein, but this improved BBB integrity is negated by the administration of AG1296, an inhibitor of platelet-derived growth factor receptor [98]

This is important because, as we discuss in Chapter 9, a solvents ability to solvate ions can have a dramatic effect on the outcome of reactions

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