tirzepatide cardiovascular outcomes trial results august 2025 SURPASS-CVOT Published: Large Confirms CVD Efficacy of Tirzepatide and the 10‐year predicted

This results in the closure of ATP-sensitive potassium (K ATP ) channels, which in turn leads to cell depolarization, the opening of voltage-dependent Ca 2 channels (VDCCs), and the subsequent influx of Ca 2

Death from cardiovascular causes

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This is tier-one cardiovascular evidence

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Within indication-based subgroups, tirzepatide used in patients with diabetes mellitus was significantly more frequently associated with gastrointestinal disorders compared with patients in weight control purpose