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The treatments with MOTS-c, exendin-4 and combination treatment reduced blood glucose levels (scrambled: 331.7 200.98 mg dl 1 , MOTS-c: 200.9 142.25 mg dl 1 , exendin-4: 127.9 16.82 mg dl 1 , exendin-4 + MOTS-c: 134.5 14.085 mg dl 1 ) and delayed the onset of diabetes at 18 weeks of age (Fig