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Tripeptides such as GHK-Cu have an established safety record in topical and cosmetic applications, showing low cytotoxicity and reduced skin irritation compared with other copper compounds, and acceptable tolerability in clinical cosmetic studies [23, 74, 93]

A history of bowel obstruction or pseudo-obstruction was noted in 9 (13.4%) patients (Table 1)

References 1.Gulewitsch W

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Bioorg Med Chem Lett 24:53575363 Bryant P, Pabst M, Badescu G, Bird M, McDowell W, Jamieson E, Swierkosz J, Jurlewicz K, Tommasi R, Henseleit K et al (2015) In vitro and in vivo evaluation of cysteine rebridged trastuzumabMMAE antibody drug conjugates with defined drug-to-antibody ratios