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It is also worth noting that in obese patients with T2DM, GLP-1RA-mediated weight reduction has been associated with the detection rate of breast cancer [34], with the highest incidence observed in patients who experienced more than 10% weight loss following treatment [35]

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Dysesthesia: A New Signal for Retatrutide The TRIUMPH-4 Phase 3 trial revealed an unexpected finding: dysesthesia (abnormal touch sensations where normal sensations feel unusual or painful) in 20.9% of participants on 12 mg and 8.8% on 9 mg, compared to 0.7% on placebo (BioSpace, Dec 2025)

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