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Neither approach is universally right or wrong

Pancreatitis : An association between GLP-1-based therapies and acute pancreatitis has been observed, though a definitive causal relationship has not been established

Receptor binding triggers Gs-mediated cAMP production, which in beta cells potentiates glucose-dependent insulin secretion

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Side Effects That Warrant Prompt Medical Attention While most GLP-1 side effects are manageable and temporary, there are specific symptoms that should prompt a call to a doctor rather than continued home management

(2022) [59] comparing GLP-1RA plus SGLT2i combination therapy to GLP-1RA and SGLT2i monotherapies among 1,895 patients with T2DM enrolled in 8 RCTs, the addition of a GLP-1RA to SGLT2i treatment showed that drug discontinuation, diarrhea, injection-site-related events, nausea, vomiting and genital infections were more likely to occur in combination therapy