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It is reported as orally active in rodents [1]

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A secondary analysis of a randomized clinical trial examined changes in BMD at clinically significant sites following an 8-week low-calorie diet (800 kcal/day) for weight loss, followed by a year-long treatment with liraglutide (3.0 mg daily), exercise alone (a supervised and progressive resistance training program), a combination of both treatments (liraglutide + exercise), or a placebo [74]

For ORLISTAT, the most common adverse events resulting in discontinuation of treatment were gastrointestinal