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25 Besides, GSTP1 negatively regulates STAT3 activation in epidermal growth factor (EGF) signaling, and is also a regulator of the cell cycle via EGF signaling in human hepatocellular carcinoma (HCC)
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Ipamorelin is another synthetic peptide that may interact with pituitary cells, although it appears to do so by triggering a different receptor called the growth hormone secretagogue (GHS) receptor
The selectivity advantage is well-supported in animal data and is pharmacologically plausible in humans, but the claim that Ipamorelin does not raise cortisol in humans is extrapolating from rat data rather than reporting a confirmed human finding