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Many women also report that, in addition to overall improved quality of life, HRT helps with the following equally annoying and potentially life-altering midlife symptoms: achy joints issues with memory and cognitive functioning mood swings, anxiety, irritability, and anger weight gain and redistribution (the shifting of fat to the midsection) It may also lead to: elevated energy levels and reduced fatigue improved skin elasticity and reduced dryness healthier hair growth True Stories of Transformation In terms of chronic disease prevention, several major medical associations, including The Menopause Society and The International Osteoporosis Foundation, endorse the use of HRT in preventing osteoporosis-related fractures in at-risk women before age 60 or within 10 years of menopause