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For tirzepatide, the average weight loss is 8.31 pounds in the first month, (not even a pound greater than semaglutide), 15.73 pounds over the first two months (almost three pounds more than semaglutide), 19.34 pounds over the first three months (a pound greater than semaglutide) and 26.40 pounds over the first four months (three pounds more than semaglutide)

GIP (glucose-dependent insulinotropic polypeptide) improves how your body processes blood sugar and works with GLP-1 to make the "I'm full" signal stronger

GLP-1(7-37) significantly stimulated insulin secretion, suggesting it plays an important role in insulin secretion (Mojsov et al 1987)

[DOI] [PubMed] [Google Scholar] 38.Pellesi L, Garcia-Azorin D, Rubio-Beltrn E, Ha W S, Messina R, Ornello R et al

Minimizing Pain or Discomfort Relax your muscles : Tension can increase pain

Adequate fluid intake matters most here