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A February 2026 study in the Journal of Clinical Endocrinology & Metabolism found an 11% higher fragility fracture risk in older adults with Type 2 diabetes using GLP-1 medications versus those using other diabetes medications - though this was a retrospective study documenting association, not proven causation

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Taken together, these results do not support major alterations in somatotropic axis function as the primary mechanism underlying Sema's growth-inhibitory effects in stunted juveniles

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