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The medication works through several interconnected mechanisms: Appetite regulation in the brain: Semaglutide acts on receptors in the hypothalamus, the area of the brain that controls hunger and satiety signals, leading to reduced appetite and food cravings

Moreover, ROS exerts an important effect on microglia as the second messenger, modifying inflammatory gene transcription and, consequently, amplifying the inflammation

GLP-1R and GIPR belong to class B1 of the G protein-coupled receptors, and share high homology and a similar action pattern

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